PDF The Equator Principles EP4 July2020
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E-type prostanoid receptor 4 (EP4) in disease and therapy
In this context, the EP4 receptor is currently emerging as most versatile and promising among PGE2 receptors. Anti-inflammatory, anti-thrombotic and vasoprotective effects have been proposed for the EP4 receptor, along with its recently described unfavorable tumor-promoting and pro-angiogenic roles.
Prostaglandin EP4 receptor - Wikipedia
The EP4 gene (PTGER4) has been identified as a negative feedback regulator of proliferation in response to BCR signals. PGE 2 in the microenvironment, acting through the EP4 receptor, negatively regulates B-cell proliferation, suggesting the EP4 receptor as a novel target for treating B-cell malignancies.
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EP4 antagonist therapy is suggested to inhibit the immune-suppressive and tumorigenic roles of PGE 2 in tumors, and it may sensitize the therapeutic effects of ICIs in patients with non-inflamed and C-IC-deficient tumors. This review provides insight into the mechanism of action of EP4 antagonists in cancer immunotherapy and suggests a C-IC ...
EP4 Receptor - an overview | ScienceDirect Topics
We found that EP4 expression correlates with an improved IBD outcome and that EP4 activation induces a transcriptional signature consistent with resolution of intestinal inflammation.
Prostaglandin E2 Receptor 4 (EP4) as a Therapeutic Target to Impede ...
Resident Alien ' s alien tracker hasn't kicked the bucket just yet. In Wednesday's episode, McCallister reached out to David Logan to pick his brain about an autonomous robotics program he ...
EP4 as a Therapeutic Target for Aggressive Human Breast Cancer
EP4 facilitates closure of ductus arteriosus at birth, induces osteogenesis, protects against inflammatory bowel disease, facilitates Langerhans cell migration and maturation, and mediates joint inflammation in collagen-induced arthritis. 4.1.2. EP Receptors in Tumorigenesis.
Anti-inflammation therapy by activation of prostaglandin EP4 receptor ...
Here, the authors identify in vivo active leads for inflammatory pain using large library docking against the EP4 prostaglandin receptor. Nature Communications - Non-addictive treatments for pain...
E-type prostanoid receptor 4 (EP4) in disease and therapy
EP4 receptor modulators can be used as drugs of specific interest. A number of EP4 receptor agonists and antagonists are at different stages of clinical development. The agonists of EP4 receptor showed promising results for ulcerative colitis (UC), bone deposition and facilitated bone resorption.
EP4 Receptor - an overview | ScienceDirect Topics
To determine the role of EP4 receptor in regulating chondrogenesis, we calculated the number of chondrocytes in each zones of the knee joints from EP4 f/f and EP4 Col2 mice at 3 months of age.